مواد با دسترسی محدود (RAMs): نوع، سازوکار و کاربرد
الموضوعات :
1 - گروه شيمي
الکلمات المفتاحية: حذف پروتئین, مواد با دسترسی محدود بر پایهی پلیمر, مواد با دسترسی محدود بر پایهی سیلیکا, مواد با دسترسی محدود بر پایهی نانولوله¬, های کربنی, مواد با دسترسی محدود بر پایهی حلّالهای فراذرهای.,
ملخص المقالة :
با وجود پیشرفت در ساخت دستگاه های مشخصه یابی، اندازهگیری غلظتهای کم مواد در محیط های پیچیده به خصوص سیالات زیستی مانند خون، پلاسما، بزاق ، شیر و...، کاری سخت وچالش برانگیز است. در حین آماده سازی این نمونه ها، نه تنها لازم است ترکیبات مزاحم از محیط حذف شوند، بلکه باید مواد مورد نظر در حین این فرایند از دست نرفته و حتی امکان تغلیظ نیز وجود داشته باشد. از این رو در تحلیل مقادیر بسیار کم مواد، مراحل آمادهسازی نمونه بیش ازپیش، اهمیت پیدا می کند. یکی از پرکاربردترین روش های آماده سازی نمونه، استخراج فاز جامد (SPE) با جاذب های پلیمری است که در صورت ادغام با مرحله ی حذف پروتئین، که به طور معمول برای نمونه های زیستی باید اجرا شود، منجر به کاهش خطا و افزایش سرعت روش پیشنهادی می شود. از جاذب های مناسب در روش SPE می توان به پلیمرهای قالب مولکولی و مواد با دسترسی محدود (RAM) اشاره کرد. تاکنون، انواع مختلفی از RAMهای پلیمری، سیلیکایی یا RAMهای اصلاحشده با نانولوله های کربنی، تولید شده و بهصورت تجاری درآمدند. استفاده از RAMها درعین سهولت در آمادهسازی نمونههای پیچیده، بازده بالایی نیز دارد. حضور گروههای آبدوست و از طرفی منافذ کوچک سبب افزایش کارایی این دسته از مواد میشود.
1. Khatibi S. A., Hamidi S., Siahi-Shadbad M. R., Current Trends in Sample Preparation by Solid-Phase Extraction Techniques for The Determination of Antibiotic Residues in Foodstuffs: AReview, Critical Reviews in Food Science and Nutrition, 0, 1–22, 2020.
2. Mullett W.M., Determination of Drugs in Biological Fluids by Direct Injection of Samples for Liquid-Chromatographic Analysis,Journal of Biochemical and Biophysical Methods,70, 263-273, 2007.
3. MoraesG.O.I., Silva L.M.R., Santos-NetoA.J., Florenzano F.H., FigueiredoE.C., A New Restricted Access Molecularly Imprinted Polymer Capped with Albumin for Direct Extraction of Drugs from Biological Matrices: The Case of Chlorpromazine in Human Plasma, Analytical and Bioanalytical Chemistry,405, 7687-7696, 2013.
4. Raabová H.,Háková M.,Havlíková L., Poly-ϵ-caprolactone Nanofibrous Polymers: A Simple Alternative to Restricted Access Media for Extraction of Small Molecules from Biological Matrixes, Analytical Chemistry, 92,6801–6805, 2020.
5. González-RubioS., García-GómezD., Ballesteros-GómezA., RubioS., A New Sample Treatment Strategy Based on Simultaneous Supramolecular Solvent and Dispersive Solid-Phase Extraction for The Determination of Ionophore Coccidiostats in All Legislated Foodstuffs,Food Chemistry, 326, 126987, 2020.
6. BoosK.S., FleischerC.T., Multidimensional On-Line Solid-Phase Extraction (SPE) Using Restricted Access Materials (RAM) in Combination with Molecular Imprinted Polymers (MIP), Fresenius' Journal of Analytical Chemistry, 371, 16-20, 2001.
7. AbrãoL. C. D. C., FigueiredoE. C., A New Restricted Access Molecularly Imprinted Fiber for Direct Solid Phase Microextraction of Benzodiazepines from Plasma Samples, Analyst,144, 4320-4330, 2019.
8. [8] SantosM.G., TavaresI.M.C., BoralliV.B., FigueiredoE.C., Direct Doping Analysis of Beta-Blocker Drugs from Urinary Samples by On-Line Molecularly Imprinted Solid-Phase Extraction Coupled to Liquid Chromatography/Mass Spectrometry, Analyst, 140, 2696-2703, 2015.
9. SantosM.G., NakamuraM.G., Santos-NetoA.J., FigueiredoE.C., Restricted Access Molecularly Imprinted Polymers Obtained by Bovine Serum Albumin and/or Hydrophilic Monomers' External Layers: AComparison Related to Physical and Chemical Properties, Analyst, 140, 7768-7775, 2015.
10. Desilets C.P., Rounds M.A.,Regnier F.E., Semipermeable-Surface Reversedphase Media for High-Performance Liquid Chromatography, Journal of Chromatography A, 544, 25-39, 1991.
11. Mendes T. V., Franqui L. S.,Santos M. G., WisniewskiC., FigueiredoE. C., Synthesis and Characterization of ANew Magnetic Restricted Access Molecularly Imprinted Polymer for Biological Sample Preparation,Materials Today Communications, 24, 101002, 2020.
12. Oliveira F.M.,Segatelli M.G., Tarley C.R.T., Preparation of ANew Restricted Access Molecularly Imprinted Hybrid Adsorbent for The Extraction of Folic Acid from Milk Powder Samples, Analytical Methods, 8, 656-665, 2016.
13. Santos M.G., TavaresI.M.C., Barbosa A.F., Bettini J., FigueiredoE.C., Analysis of Tricyclic Antidepressants in Human Plasma Using Online-Restricted Access Molecularly Imprinted Solid Phase Extraction Followed by Direct Mass Spectrometry Identification/Quantification, Talanta, 163, 8-16, 2016.
14. Cook S.E., Pinkerton T.C., Characterization of Internal Surface Reversed-Phase Silica Supports for Liquid Chromatography, Journal of Chromatography A, 368, 233-248, 1986.
15. Desilets C.P., Rounds M.A., Regnier F.E., Semipermeable-Surface Reversed- Phase Media for High-Performance Liquid Chromatography,Journal of Chromatography A, 544, 25-39,1991.
16. RudolphiA., Boos K.S., The Use of Restricted-Access Media in HPLC, Part I -Classification and Review, LC-GC,15, 602-611, 1997.
17. Cassiano N.M., Lima V.V., Oliveira R.V., De Pietro A.C., Cass Q.B., Development of Restricted-Access Media Supports and Their Application to The Direct Analysis of Biological Fluid Samples via High Performance Liquid Chromatography, Analytical and Bioanalytical Chemistry, 384, 1462-1469, 2006.
18. Wang H., Jiang P., Zhang M., DongX., Synthesis of ANovel Restricted Access Chiral Stationary Phase based on Atom Transfer Radical Polymerization and Click Chemistry for The Analysis of Chiral Drugs in Biological Matrices, Journal of Chromatography A,1218, 1310-1313, 2011.
19. Willemsen O., Machtejevas E., Unger K.K., Enrichment of Proteinaceous Materials on AStrong Cation-Exchange Diol Silica Restricted Access Material: Protein-Protein Displacement and Interaction Effects, Journal of Chromatography A, 1025, 209-216, 2004.
20. Gisch D.J., Hunter B., Feibush B., Shielded Hydrophobic Phase: ANew Concept for Direct Injection Analysis of Biological Fluids by High-Performance Liquid Chromatography, Journal of Chromatography B: Biomedical Sciences and Applications, 433, 264-268, 1988.
21. Liu S., Li Y., Deng C., Mao Y., Zhang X., Yang P., Preparation of Magnetic Coremesoporous Shell Microspheres with C8-Modified Interior Pore-Walls and Their Application in Selective Enrichment and Analysis of Mouse Brain Peptidome, Proteomics, 11, 4503-4513, 2011.
22. Haginaka J., Wakai J., Preparation and Characterization of Mixed Functional Phase Silica Materials Using Phenyl-, Butyl- or Octylchlorosilane as ASilylating Agent, Journal of Chromatography A, 596, 151-156, 1992.
23. [23]WangC., Li M., Xu H., Wei Y., Preparation of An Internal Surface Reversedphase Restricted-Access Material for The Analysis of Hydrophobic Molecules in Biological Matrices,Journal of Chromatography A, 1343, 195-199, 2014.
24. [24]Ruckmick S.C., Hench B.D., Direct Analysis of The Dopamine Agonist (-)-2-(Npropyl- N-2-Thienylethylamino )-5-Hydroxytetralin Hydrochloride in Plasma by High-Performance Liquid Chromatography Using Two-Dimensional Column Switching, Journal of Chromatography B: Biomedical Sciences and Applications, 565, 277-295, 1991.
25. Nageswara RaoR., ShindeD.D., Two-dimensional LC-MS/MS Determination of Antiretroviral Drugs in Rat Serum and Urine, Journal of Pharmaceutical and Biomedical Analysis, 50, 994-999, 2009.
26. Kanda T., Shirota O., Ohtsu Y., Yamaguchi M., Synthesis and Characterization of Polymer-Coated Mixed-Functional Stationary Phases with Several Different Hydrophobic Groups for Direct Analysis of Biological Samples by Liquid Chromatography, Journal of Chromatography A, 722, 115-121, 1996.
27. De Paula F.C.C.R., De PietroA.C., Cass Q.B., Simultaneous Quantification of Sulfamethoxazole and Trimethoprim in Whole Egg Samples by Columnswitching High-Performance Liquid Chromatography Using Restricted Access Media Column for On-Line Sample Clean-Up, Journal of Chromatography A, 1189, 221-226, 2008.
28. Belaz K.R.A., Pereira-Filho E.R., Oliveira R.V., Development of Achiral and Chiral 2D HPLC Methods for Analysis of Albendazole Metabolites in Microsomal Fractions Using Multivariate Analysis for The in Vitro Metabolism, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 932, 26-33, 2013.
29. Gomes R.A.B., Luccas P.O., De Magalhaes C.S., De Figueiredo E.C., Evaluation of The pH Influence on Protein Exclusion by Restricted Access Carbon Nanotubes Coated with Bovine Serum Albumin, Journal of Materials Science, 51, 7407-7414, 2016.
30. Ullah N., Shah F., Khan R.A., Ateeq M., Muhammad H., Khan A.R., Restricted Access-Activated Carbon Clothes-Based Lead Extraction from Human Serum: Skipping The Sample Preparation Step for Biological Media, International Journal of Environmental Analytical Chemistry, 96, 1048-1058, 2016.
31. Ballesteros-Gomez A., Sicilia M.D., Rubio S., Supramolecular Solvents in The Extraction of Organic Compounds. A review, Analytica Chimica Acta, 677, 108-130, 2010.
32. Caballero-Casero N., Çabuk H., Martínez-Sagarra G., Devesa J.A., Rubio S., Nanostructured Alkyl Carboxylic Acid-Based Restricted Access Solvents: Application to The Combined Microextraction and Cleanup of Polycyclic Aromatic Hydrocarbons in Mosses, Analytica Chimica Acta, 890, 124-133, 2015.